4 Supplements You Shouldn’t Take for Longevity

Aging gracefully is a goal many aspire to achieve, and living a long, healthy life often becomes a top priority as we grow older. With countless products and supplements advertised as “the key to youthful vitality,” it’s easy to feel overwhelmed or confused about what truly contributes to healthy aging. The supplement aisle, filled with promises of better energy, stronger bones, sharper minds and radiant skin, can be alluring but also misleading. Not everything labeled as a “health booster” is as beneficial as it may seem.

While supplements can be helpful to address specific deficiencies or support overall health (especially as we age), not all are created equal. And some may even do more harm than good. It’s crucial to approach supplementation with a cautious and informed mindset, ensuring that your choices are based on science rather than marketing. In this article, we’ll highlight some supplements you’re better off avoiding and explain why they may work against your goal of living a long and vibrant life.

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1. Iron

Iron is essential for maintaining healthy red blood cells and ensuring efficient oxygen transport throughout the body. However, iron supplements may not be the best choice if your goal is aging healthily. 

“I don’t recommend taking iron supplements for healthy aging unless there is a specific reason and they are prescribed by your doctor,” explains Elizabeth Ward, M.S., RDN, registered dietitian nutritionist and co-author of the book The Menopause Diet Plan. “Excess iron can build up in the liver, heart and pancreas in people with hemochromatosis, an inherited condition that causes you to absorb a lot of iron. You may not know that you have this condition, which occurs in 1 in 200 to 400 people and often goes undiagnosed, so better safe than sorry,” she adds.

“Too much iron can also interact with certain medications, decreasing their effectiveness,” notes Ward. 

Ward explains that some older people need iron supplements, including those with iron-deficiency anemia due to chemotherapy or certain gastrointestinal disorders, such as celiac disease or those with chronic heart failure. However, blindly taking iron supplements for longevity is not recommended for the generally healthy population, especially older people. 

2. Resveratrol

Resveratrol is a natural compound found in grapes, red wine and certain berries, known for its antioxidant properties. It is often touted for its potential to support heart health and combat aging.

“Despite its popularity and promising findings in animal studies, the doses required to replicate the effects seen in these studies are far higher than what is typically available in supplements,” shares Vanessa Imus, M.S., RDN. “Therefore, while resveratrol may offer some health benefits, it is often considered more hype than worth as a standalone supplement for healthy aging,” she adds. 

One systematic review suggests there is currently no conclusive clinical evidence to advocate its recommendation in any healthcare setting. High doses of resveratrol in supplement form may also interfere with certain medications, such as blood thinners, and could lead to gastrointestinal side effects.

3. Vitamin C

Vitamin C, also known as ascorbic acid, is a vital nutrient that supports immune function, skin health, and iron absorption from plant-based foods. It is a powerful antioxidant that helps protect cells from damage caused by free radicals.

Yet while vitamin C is an essential nutrient to include in one’s diet, Johannah Katz, MA, RD, an Orlando-based registered dietitian, suggests that excessive doses of vitamin C can potentially interfere with the body’s natural defense mechanisms. “Studies have shown that high levels of exogenous antioxidants, including vitamin C, might suppress the body’s endogenous antioxidant response system, which is more powerful in combating oxidative stress,” explains Katz.

“Moreover, the body tightly regulates vitamin C absorption and excess amounts are typically excreted, offering no added benefit and possibly causing side effects like gastrointestinal discomfort,” adds Katz. 

4. Vitamin E

Vitamin E is a fat-soluble antioxidant that plays a critical role in protecting cells from oxidative damage caused by free radicals. Research indicates that vitamin E supplements should not be relied upon for longevity support due to a lack of consistent evidence demonstrating their effectiveness in extending lifespan. While vitamin E is known for its antioxidant properties, studies exploring its impact on longevity have produced mixed results.

Some research has even suggested that high doses of supplemental vitamin E may do more harm than good by disrupting the body’s natural oxidative balance and potentially increasing the risk of certain diseases, like cardiovascular issues or certain types of cancer. Antioxidants, when consumed in isolated, high amounts, can sometimes interfere with the body’s normal cellular processes, leading to unintended adverse effects rather than the desired health benefits.

Tips for Healthy Aging

Healthy aging doesn’t have to be complicated—it’s all about making small, intentional choices that support your body and mind over time. Here are some simple, manageable tips to get you started:

• Eat a Colorful Diet: Focus on whole foods like fruits, vegetables, whole grains, lean proteins and healthy fats. A colorful plate is not only appealing but also packs a variety of nutrients your body needs.
• Stay Active: Regular exercise is key. Whether walking, yoga, swimming or dancing, find activities you enjoy and stick to them. Even 30 minutes a day can make a big difference!
• Prioritize Sleep: Quality sleep allows your body to repair and recharge. Aim for 7–9 hours each night and establish a consistent sleep routine to help your body clock stay on track.
• Keep Your Mind Engaged: Challenge your brain with puzzles, reading or learning something new. Staying mentally active can help maintain cognitive health as you age.
• Stay Hydrated: Drinking enough water is essential for everything from digestion to skin health. Keep a water bottle handy to remind yourself to sip throughout the day.
• Stay Connected: Maintain strong relationships and social connections with friends, family or community groups. Emotional support plays a vital role in overall well-being.

The Bottom Line

While it’s tempting to turn to supplements that promise to boost longevity, it’s important to approach them with caution. Many products on the market make bold claims but lack solid scientific backing, or worse, they may pose risks to your health when taken unnecessarily. While certain supplements can help with healthy aging, it is best to first focus on building a strong foundation for your health through balanced nutrition, regular physical activity, quality sleep and meaningful social connections. Your body thrives on these natural, time-tested care methods far more than on quick-fix solutions.

Remember, there’s no substitute for a healthy lifestyle, and the key to longevity lies in simple, mindful choices that support your overall well-being. If you’re considering taking a supplement, always talk to your healthcare provider to ensure it’s safe and truly needed for your situation. By staying informed and prioritizing evidence-based practices, you can take the guesswork out of aging gracefully.