How the Axolotl’s Unique Regenerative Power Is Inspiring Skin Science

Regenerative beauty is emerging as a growing category and few creatures are more emblematic of its potential than the axolotl—a unique salamander with the rare ability to regenerate limbs, parts of its heart and even brain tissue. Inspired by this “water dragon,” the new aesthetic company RegenX is using axolotl biology to develop skin care that promotes skin healing and renewal. While it may sound like science fiction, RegenX combines axolotl-inspired science with advanced technology to harness the skin’s regenerative power in ways that could redefine beauty treatments.

Featured Experts

• Dr. Jill Waibel is a board-certified dermatologist in Miami
• Beth Corson, CEO of RegenX

Super-Powered Skin Care

“This falls squarely in the realm of regenerative medicine, which is arguably the hottest field in aesthetics right now. We’re not just hydrating the skin; we’re actually aiming to recreate youthful, functioning tissue by activating regenerative pathways,” explains Miami dermatologist Jill Waibel, MD. “RegenX is tapping into the biology of the axolotl, the most regenerative animal ever studied in a lab, to take skin care in a new direction.”

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According to RegenX CEO Beth Corson, the brand’s breakthrough comes from isolating the axolotl’s extracellular matrix (ECM), which offers unique scaffolding for scarless healing and cellular renewal. “Their regenerative abilities are unmatched,” says Corson. “We wanted to translate this biological phenomenon into skin care, giving the skin an enhanced capacity for repair and rejuvenation.”

Accelerated Healing

RegenX’s formulations are gaining attention in both daily skin care and post-procedural care. Dr. Waibel shares that patients see enhanced healing after treatments like microneedling. “We’re activating a specific set of genes responsible for skin repair and longevity,” she says. RegenX’s technology works with the skin’s biology to achieve visibly smoother, healthier results, all while being cruelty-free.

“We did biopsies and were able to show, through gene expression, that there was more collagen stimulation within seven days. Patients also had decreased sun damage, and this was highly effective in combination with a nonablative laser,” Dr. Waibel notes.

While the products aren’t available yet, Dr. Waibel mentions they are coming soon. “They are still in trials and may be licensed to larger pharmaceutical companies in the future. The three products currently in development are Hydrate, Rejuvenate and Restore—each designed to enhance skin regeneration post-treatment, with Restore specifically being tested for use after Fraxel laser procedures.”

Cruelty-Free Formulations

 “Our cosmetics line is completely cruelty-free,” explains Corson, noting that the active ingredients are lab-grown rather than harvested from animals. “We use purified, secreted bioactive molecules inspired by the axolotl’s regenerative properties, which are synthesized in the lab. So, there’s no harm to animals and we’re able to maintain the powerful regenerative benefits.”

Collagen Builder

As regenerative medicine gains traction, these axolotl-inspired formulations stand at the forefront, says Dr. Waibel. “Their axolotl-inspired products upregulate genes tied to collagen production, cell renewal and anti-inflammation, opening doors to treatments for acne scars, wrinkles and more. This could transform how we treat aging and skin quality concerns,” she adds.