The Ceramide Cream Readers in Their 40s Say Makes Skin ‘Baby Soft’

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Moisturizers that worked wonders in your twenties and thirties often lose their magic as skin matures. That’s because lipid production naturally declines over time, leading to dryness, dullness and a loss of firmness. SkinCeuticals Triple Lipid Restore 2:4:2 ($155) is formulated to address exactly that, and it’s become a go-to for NewBeauty readers in their 40s.

In a recent survey of more than 400 NewBeauty readers,* we asked them to name their holy-grail skin-care product. For many in their 40s, SkinCeuticals Triple Lipid Restore 2:4:2 was the clear winner. One 47-year-old respondent shared, “The feel and the results are better than any other products I’ve tried.” Another, 41, said, “I love how it makes my skin baby soft and looking young. I love the ceramides. The results are proven, and I can see them. I would recommend it to all my friends.”

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BUY ON SKINCEUTICALS – $155

BUY ON DERMSTORE – $155

The name 2:4:2 refers to its precise ratio of 2% pure ceramides, 4% natural cholesterol, and 2% fatty acids—a clinically backed blend that helps restore skin’s barrier, improve elasticity and smooth texture. The fast-absorbing formula also includes vitamin E and antioxidant-rich essential oils to fight free-radical damage and support natural cell repair.

The result? Skin that looks fuller, feels softer and glows with renewed radiance. It’s paraben- and dye-free, and ideal for normal, dry and aging skin types. If your skin is feeling depleted and your old moisturizer just isn’t cutting it, this cult-favorite cream might be the upgrade your routine needs.

*Source: BeautyEngine Advanced Research, 2025

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